Journal: iScience
Article Title: A quantitative metabolic signature of host response during SARS-CoV-2 infection and recovery
doi: 10.1016/j.isci.2026.115390
Figure Lengend Snippet: Metabo-time confidently represented individualized normalization of host systemic oxidative stress and immune response during COVID-19 recovery, better than physical days since hospitalization (A) The normalization of serum reactive oxygen species levels during recovery was better captured by metabo-time than physical days since hospitalization, as evidenced by the higher R 2 statistic correlating ROS levels with metabo-time than days since hospitalization. This was quantitatively tested by joint linear modeling of ROS on both physical time and metabo-time. (B) Quantification and statistical analysis; ( n = 34), where the conditional regression coefficient (i.e., association) of physical time with ROS was null. Still, the effect of metabo-time remained highly significant, suggesting that metabo-time can fully replace physical time to characterize the individualized recovery of ROS levels. (C) Longitudinal correlation of host serum cytokine levels versus metabo-time and physical time yielded consistent findings across cytokines. (D) Cytokines identified as statistically significantly correlated with metabo-time (i.e., “normalizing” during COVID-19 recovery) were consistent with previous observations ( n = 36). , ,
Article Snippet: Correlation between Metabo-time and log-transformed CRP values was assessed using Spearman’s rank correlation coefficient.
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